Description

Lesfal Phosphatidylcholine 250 mg – 5 ampoules.

Composition and Dosage Form:

The medication is a solution for injection presented in 5 ml ampoules, containing 50 mg/ml of Soybean Phosphatidylcholine.

Pharmacological Properties:

Lesfal Phospholipidcholine contains phospholipids that closely resemble the chemical structure of those naturally found in the body, but with higher levels of essential fatty acids. These phospholipids play a crucial role in repairing damaged liver tissue by incorporating into cell membranes. They also regulate lipid metabolism by controlling lipoprotein metabolism. This leads to an improved ability of HDL to bind with cholesterol and converts neutral fats and cholesterol into forms that can be transported and oxidized. Furthermore, the presence of phospholipids in the biliary tract reduces the lithogenic index and stabilizes the bile.

The half-life of choline is 66 hours, while that of saturated fatty acids is 32 hours. Kinetic studies have indicated that only a small percentage (5% or less) of both 3H and 14C isotopes are excreted in the feces.

Indications:

Lesfal Phospholipidcholine is indicated for the treatment of the following conditions:

• Fatty liver
• Acute and chronic hepatitis
• Liver cirrhosis
• Pre- and postoperative care for patients undergoing liver and biliary tract surgery
• Toxic liver injury
• Toxemia in pregnant women
• Psoriasis
• Radiation syndrome

The dosage and administration method of this medication should be determined by a healthcare provider. It is crucial to follow the instructions provided by the doctor or pharmacist to ensure safe and effective use of the medication.

For the treatment of psoriasis, it is recommended to start with two weeks of oral phosphatidylcholine followed by ten intravenous injections of 5 ml along with PUVA therapy. The medication should be slowly injected intravenously as intramuscular injection may cause a local reaction. The recommended daily dosage for adults and children over 12 is 5-10 ml, and for severe cases, 10-20 ml. If dilution is required, it should be done in a 1:1 ratio with the patient’s blood. If not possible, electrolyte-free solutions such as 5% or 10% glucose solution or 5% xylitol solution can be used. Treatment should continue for up to 10 days, followed by a switch to oral phosphatidylcholine.

Contraindications:

Lesfal Phospholipidcholine is contraindicated in individuals who are hypersensitive to any of the drug components.

Adverse Effects:

In some instances, high doses of the medication may cause digestive issues such as diarrhea. Additionally, hypersensitivity reactions, rashes, and itching may occur.

Special Warnings and Precautions for Use:

Precautions: The medication contains 5.02 mg/ml of alcohol and is for intravenous injections only. Pregnant women can use the medication to treat toxemia, and it is not contraindicated during lactation. Lesfal Phospholipidcholine is prescribed for children over 12 years of age, and it does not affect the ability to drive or use machines.

Interaction with Other Medicinal Products and Other Forms of Interaction:

When administering any medication, it is important to consider interactions with other medicinal products and other forms of interaction. It is crucial to research and understand the potential interactions between different drugs, as well as other forms of interaction, such as the effects of food, alcohol, and lifestyle choices.

Overdose:

No cases of overdose have been reported.

Storage Conditions:

Store at 2–8°C. Protect from light.